| Title | A clinical trial of long-term oral salbutamol in reversible diffuse airway obstruction [abstract no: 2] |
| CRGReportID | 55584 |
| Authors | Epstein SW, Barnard JA, Zsoter TT |
| Journal | Indian journal of chest diseases and allied sciences |
| Year | 1974 |
| Volume | 16 |
| Issue | |
| Pages | 131-2 |
| Abstract | A double blind, cross-over trial of the Beta-Adrenergic stimulating drug, salbutamol, was carried out in 16 volunteers. The drug (2 mg) or placebo was administered as 1 tablet 4 limes a day for I week and 2 tablets 4 times a day for a second week. Daily diaries were kept that included readings of peak expiratory flow performed in triplicate twice a day. The active drug could be predicted based on the patient's assessment (P < 0.01), on the physicians assessment (P< 0.01), and improvement in the subject's peak expiraton flow (P< 0.01). Peak expiratory flow increased significantly (P < 0.001) for the group while taking salbutamol as compared with the placebo. No difference was noted between the week during which 2 mg of salbutamol was given 4 times a day and the week when 4 mg was given 4 times a day. Neuromuscular side effects were noted in 6 of the 16 subjects. |
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| Study_Design | CCT |
| City | India |
| Keywords | |
| Address | Amer. Rev. Resp. Dis. 108, 1367, 1973 |